## Abstract ## BACKGROUND Anecdotal cases of chromosomal abnormalities in Philadelphia chromosome (Ph)‐negative metaphases have been reported in patients with chronic myelogenous leukemia (CML) in the chronic phase during treatment with interferon and, more recently, with imatinib. This phenomenon
Results of imatinib mesylate therapy in chronic myelogenous leukaemia with variant Philadelphia chromosome
✍ Scribed by Maha M. T. El-Zimaity; Hagop Kantarjian; Moshe Talpaz; Susan O'Brien; Francis Giles; Guillermo Garcia-Manero; Srdan Verstovsek; Deborah Thomas; Alessandra Ferrajoli; Kimberly Hayes; B. Nebiyou Bekele; Xian Zhou; Mary B. Rios; Armand B. Glassman; Jorge E. Cortes
- Book ID
- 108672587
- Publisher
- John Wiley and Sons
- Year
- 2004
- Tongue
- English
- Weight
- 134 KB
- Volume
- 125
- Category
- Article
- ISSN
- 0007-1048
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
## Abstract ## BACKGROUND. The prognosis of patients with chronic myelogenous leukemia (CML) after failure of imatinib mesylate therapy is not well documented. ## METHODS. The outcome of 420 patients with CML post‐imatinib failure (resistance‐recurrence in 374; toxicities in 46) were reviewed in
## Abstract ## BACKGROUND Older age is a consistent poor prognostic factor in patients with Philadelphia chromosome (Ph)‐positive chronic myelogenous leukemia (CML). Whether this is related to an intrinsic worse disease biology or to inadequate drug delivery or excessive treatment‐associated toxic
## Abstract ## BACKGROUND The International Randomized study of Interferon‐alpha plus cytarabine (IFN‐α plus ara‐C) versus STI571 (imatinib mesylate) [IRIS trial] in patients with newly diagnosed Philadelphia chromosome (Ph)‐positive, chronic‐phase chronic myelogenous leukemia (CML) has not shown