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An update on the pathophysiology and genetics of restless legs syndrome

✍ Scribed by Lynn Marie Trotti; Srinivas Bhadriraju; David B. Rye


Publisher
Springer
Year
2008
Tongue
English
Weight
285 KB
Volume
8
Category
Article
ISSN
1528-4042

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Update of the pathophysiology of the Res
✍ Walter Paulus; Pascal Dowling; Roselyne Rijsman; Karin Stiasny-Kolster; Claudia πŸ“‚ Article πŸ“… 2007 πŸ› John Wiley and Sons 🌐 English βš– 207 KB

The Restless Legs Syndrome (RLS) is a heterogeneous disease. Symptomatic or secondary forms encompass iron deficiency, uremia, pregnancy, polyneuropathy, and other causes. The so-called idiopathic RLS syndrome preferentially affects patients with a younger onset before the age of 30. Here we summari

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Several studies demonstrated that 60% of restless legs syndrome (RLS) patients have a positive family history and it has been suggested that RLS is a highly hereditary trait. To date, several loci have been mapped but no gene has been identified yet. Phenocopies and possible nonpenetrants made it di