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An unusual reductive ring-opening of the 1,2,3,5,6,7-hexaazaacenaphthylene ring system

✍ Scribed by Andrew M. Kawasaki; Leroy B. Townsend

Publisher
Elsevier Science
Year
1989
Tongue
French
Weight
232 KB
Volume
30
Category
Article
ISSN
0040-4039

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✦ Synopsis

Studies on an unexpected reaction involving a reductive cleavage of the pyridazine moiety of a tricyclic heterocycle are described. Structure assignments for the products obtained from the reductive cleavage were made using physicochemical methods. The pro drug' (TCN-P, fi) of 6-amino-4-N-methyl-8-(P-D-ribofuranosyl)-I ,3,4,5&pentaaza-acenaphthylene2 (TCN, b) is currently undergoing clinical trials under the auspices of the National Cancer Insritute.3 It is generally thought that both TCN and TCN-P are acting as adenosine analogs4 but the exact biochemical mechanism has not yet been elucidated. It has been reported that a ring scissinn of the

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