An Unusual DNA Adduct Derived from the Powerfully Mutagenic Environmental Contaminant 3-Nitrobenzanthrone
β Scribed by Enya, Takeji; Kawanishi, Masanobu; Suzuki, Hitomi; Matsui, Saburo; Hisamatsu, Yoshiharu
- Book ID
- 126778310
- Publisher
- American Chemical Society
- Year
- 1998
- Tongue
- English
- Weight
- 112 KB
- Volume
- 11
- Category
- Article
- ISSN
- 0893-228X
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## Abstract 3βNitrobenzanthrone (3βNBA) is an environmental pollutant and suspected human carcinogen found in emissions from diesel and gasoline engines and on the surface of ambient air particulate matter; human exposure to 3βNBA is likely to occur primarily via the respiratory tract. In our study
Diesel exhaust is known to induce tumors in animals and is suspected of being carcinogenic in humans. Of the compounds found in diesel exhaust and in airborne particulate matter, 3-nitrobenzanthrone (3-NBA), is a particularly powerful mutagen. We investigated the capacity of 3-NBA to form DNA adduct
## Abstract 3βnitrobenzanthrone (3βNBA) is an extremely potent mutagen in the Salmonella reversion assay and a suspected human carcinogen identified in diesel exhaust and in ambient airborne particulate matter. To evaluate the in vivo mutagenicity of 3βNBA, we analyzed the mutant frequency (MF) in