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An Unusual DNA Adduct Derived from the Powerfully Mutagenic Environmental Contaminant 3-Nitrobenzanthrone

✍ Scribed by Enya, Takeji; Kawanishi, Masanobu; Suzuki, Hitomi; Matsui, Saburo; Hisamatsu, Yoshiharu


Book ID
126778310
Publisher
American Chemical Society
Year
1998
Tongue
English
Weight
112 KB
Volume
11
Category
Article
ISSN
0893-228X

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## Abstract 3‐Nitrobenzanthrone (3‐NBA) is an environmental pollutant and suspected human carcinogen found in emissions from diesel and gasoline engines and on the surface of ambient air particulate matter; human exposure to 3‐NBA is likely to occur primarily via the respiratory tract. In our study

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Diesel exhaust is known to induce tumors in animals and is suspected of being carcinogenic in humans. Of the compounds found in diesel exhaust and in airborne particulate matter, 3-nitrobenzanthrone (3-NBA), is a particularly powerful mutagen. We investigated the capacity of 3-NBA to form DNA adduct

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