An Organocatalytic [3 + 2] Cyclization Strategy for the Highly Enantioselective Synthesis of Spirooxindoles. -Phosphine-promoted [3 + 2] annulation reactions between electron-poor allenes and 3-arylidene indolin-2-ones afford a new organocatalytic strategy for the synthesis of the spirocyclic core o
An Organocatalytic [3+2] Cyclisation Strategy for the Highly Enantioselective Synthesis of Spirooxindoles
β Scribed by Dr. Arnaud Voituriez; Nathalie Pinto; Mathilde Neel; Pascal Retailleau; Dr. Angela Marinetti
- Publisher
- John Wiley and Sons
- Year
- 2010
- Tongue
- English
- Weight
- 258 KB
- Volume
- 16
- Category
- Article
- ISSN
- 0947-6539
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We thank Dr. Paul A. Lartey (Abbott Laboratories) for a generous gift of erythromycin A for use as a source of d-desosamine and l-cladinose, and we are grateful to Dr. Erica Kraynack and Dr. Philippe Breton for conducting exploratory glycosylation studies.
Highly Enantioselective Organocatalytic Cascade Reaction for the Synthesis of Piperidines and Oxazolidines. -Organocatalyzed Michael addition of amidomalonates, e.g. (I) and (VI), towards enals (II) followed by intramolecular hemiaminal formation provides enantioenriched piperidine derivatives (III)
## Abstract Hydroxyalkylβ or aminoalkylβsubstituted Nβfused heteroaromatic compounds are efficiently accessed.