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An on-line method for the preparation of n.c.a. [11CH3]trifluoromethanesulfonic acid methyl ester

✍ Scribed by M. Holschbach; M. Schüller

Publisher
Elsevier Science
Year
1993
Tongue
English
Weight
169 KB
Volume
44
Category
Article
ISSN
0969-8043

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✦ Synopsis

An improved on-line synthesis of the powerful methylation reagent, ["CH,]methyl triflate, 1, is described.

By means of a simple and cheap column technique

this reagent is synthesized in an overall reaction time of 12 min in reproducible radiochemical yields of 90% (based on "CO,), a radiochemical purity of 99% and a mean sp. act. of > 6000 Ciimmol.

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