An Iterative Catalytic Route to Enantiopure Deoxypropionate Subunits: Asymmetric Conjugate Addition of Grignard Reagents to α,β-Unsaturated Thioesters
✍ Scribed by Des Mazery, Renaud; Pullez, Maddalena; López, Fernando; Harutyunyan, Syuzanna R.; Minnaard, Adriaan J.; Feringa, Ben L.
- Book ID
- 121268630
- Publisher
- American Chemical Society
- Year
- 2005
- Tongue
- English
- Weight
- 47 KB
- Volume
- 127
- Category
- Article
- ISSN
- 0002-7863
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A catalytic asymmetric conjugate addition reaction of organocopper reagents, generated from copper salt, a chiral phosphine, and Grignard reagent, with cyclohexenone is highly dependent on the counter anion of copper species, solvents, Grignard reagents, and the structure of the chiral phosphine. Th