In this study HLA-DQA1 and TNF genes in addition to HLA-DQB1 gene were investigated at DNA level for elucidation of the genetic backgrounds of Type 1 (insulin-dependent) diabetes mellitus in Japanese subjects. DNA, amplified by polymerase chain reaction, was subjected to allele specific oligonucleot
โฆ LIBER โฆ
An investigation of Japanese subjects maps susceptibility to type 1 (insulin-dependent) diabetes mellitus close to the DQA1 gene
โ Scribed by Jacobs, K.H.; Jenkins, D.; Mijovic, C.; Penny, M.; Uchigata, Y.; Cavan, D.; Hirata, Y.; Otani, T.; Fletcher, J.; Barnett, A.H.
- Book ID
- 122350990
- Publisher
- Elsevier Science
- Year
- 1992
- Tongue
- English
- Weight
- 429 KB
- Volume
- 33
- Category
- Article
- ISSN
- 0198-8859
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Trans-racial analysis of disease associations has improved mapping of MHC-linked susceptibility to Type 1 (insulin-dependent) diabetes mellitus. In this study the contributions of the MHC class II DQA1 and DQB1 genes were investigated. Sequence-specific oligonucleotide gene probing in Type 1 diabeti