An investigation of candidate regions for association with bipolar disorder

✍ Scribed by Jo Knight; Nanette S. Rochberg; Scott F. Saccone; John I. Nurnberger Jr.; John P. Rice

• Publisher: John Wiley and Sons
• Year: 2010
• Tongue: English
• Weight: 168 KB
• Volume: 153B
• Category: Article
• ISSN: 1552-4841
• DOI: 10.1002/ajmg.b.31100

✦ Synopsis

Abstract

We performed a case–control study of 1,000 cases and 1,028 controls on 1,509 markers, 1,139 of which were located in a 8 Mb region on chromosome 6 (105–113 Mb). This region has shown evidence of involvement in bipolar disorder (BP) in a number of other studies. We find association between BP and two SNPs in the gene LACE1. SNP rs9486880 and rs11153113 (both have P‐values of 2 × 10^−5^). Both P‐values are in the top 5% of the distribution derived from null simulations (P = 0.02 and 0.01, respectively). LACE is a good candidate for BP; it is an ATPase. We genotyped 173 other markers in 17 other positional and/or functional loci but found no further evidence of association with BP. © 2010 Wiley‐Liss, Inc.