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An intramolecular cycloaddition-sigmatropic rearrangement approach to (±) gascardic acid

✍ Scribed by Gervais Bérubé; Alex G. Fallis

Publisher
Elsevier Science
Year
1989
Tongue
French
Weight
312 KB
Volume
30
Category
Article
ISSN
0040-4039

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✦ Synopsis

A general intramolecular Diels-Alderanionic oxy-Cope strategy for the synthesis of tricyclic skeletons and its application to the preparation of the gascardic acid precursor 12 is described. in situ generation of the appropriate cyclopentadiene 5 by isomerization (Et,N) afforded the [4+2] adduct directly or

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