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An intramolecular cycloaddition approach to pyrrolo[3,2-c]quinolones

✍ Scribed by Yong He; Hossen Mahmud; Brian R Wayland; H.V.Rasika Dias; Carl J Lovely

Publisher
Elsevier Science
Year
2002
Tongue
French
Weight
86 KB
Volume
43
Category
Article
ISSN
0040-4039

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✦ Synopsis

An approach to pyrrolo[3,2-c]quinolones is described which relies on an intramolecular azomethine ylide alkene cycloaddition reaction. Critical to the success of this reaction was the requirement for alkylation of the aniline nitrogen, in the absence of this substituent a decarboxylative-Michael addition pathway was observed.

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