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An integrated view of the regulation of NKG2D ligands

✍ Scribed by Noam Stern-Ginossar; Ofer Mandelboim

Book ID
108782617
Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
241 KB
Volume
128
Category
Article
ISSN
0019-2805

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## Abstract NKG2D operates as an activating receptor on natural killer (NK) cells and costimulates the effector function of Ξ±Ξ² CD8^+^ T cells. Ligands of NKG2D, the MHC class I chain‐related (MIC) and UL16 binding protein (ULBP) molecules, are expressed on a variety of human tumors, including melan