An Integrated Genetic and Physical Map of the Autosomal Recessive Polycystic Kidney Disease Region
✍ Scribed by Xose M. Lens; Luiz F. Onuchic; Guanqing Wu; Tomohito Hayashi; Martin Daoust; Toshio Mochizuki; Lorenzo B. Santarina; John M. Stockwin; Gabi Mücher; Jutta Becker; William E. Sweeny Jr.; Ellis D. Avner; Lisa Guay-Woodford; Klaus Zerres; Stefan Somlo; Gregory G. Germino
- Book ID
- 115613787
- Publisher
- Elsevier Science
- Year
- 1997
- Tongue
- English
- Weight
- 95 KB
- Volume
- 41
- Category
- Article
- ISSN
- 0888-7543
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Autosomal recessive polycystic kidney disease (ARPKD) is one of the most common hereditary renal cystic diseases and has a high infant mortality. Prenatal diagnosis using fetal sonography can be unreliable, especially in early pregnancy. The ARPKD locus has been mapped to proximal chromosome 6p allo
The autosomal dominant form of polycystic kidney disease (ADPKD) has been linked to the alpha-globin gene locus on 16p. Linkage studies between the autosomal recessive type (ARPKD) and the 3' HVR of the alpha-globin gene cluster showed that the ARPKD and ADPKD are not allelic.