Murine + ˇT cells participate in innate immune response against infection of the intracellular bacterium Listeria monocytogenes. In the present report, we analyzed the mechanism of the + ˇT cell-mediated response against L. monocytogenes infection. + ˇT cell-enriched spleen cells of L. monocytogenes
An innate view of γδ T cells
✍ Scribed by Richard Boismenu; Wendy L Havran
- Publisher
- Elsevier Science
- Year
- 1997
- Tongue
- English
- Weight
- 677 KB
- Volume
- 9
- Category
- Article
- ISSN
- 0952-7915
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✦ Synopsis
Findings made during the past few years demonstrate that y8 T cells apparently share with macrophages a propensity to recognize nonpeptidic molecules of the kind most commonly associated with microorganisms and stressed cells. In general, recognition of these antigens by y8 T cells involves the antigen receptor but does not require antigen presenting cells to express MHC gene products or to have a functional antigen processing machinery. Other recent advances continue to support the notion that y8 T cells can perform specialized functions related to the repair of tissue damage.
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~6 T cells consist of multiple lineages of cells with distinct antigen receptor repertoires, tissue localization and function. Recent evidence suggests that the ordered appearance of these sublineages during development is a result of programed rearrangement of Vy-gene segments. It appears that the