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An informative polymorphism detectable by polymerase chain reaction at the 3′ end of the dystrophin gene

✍ Scribed by C. Oudet; R. Heilig; J. L. Mandel

Publisher: Springer
Year: 1990
Tongue: English
Weight: 342 KB
Volume: 84
Category: Article
ISSN: 0340-6717
DOI: 10.1007/bf00200576

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✦ Synopsis

A fragment that contains a (CA)n sequence from the 3' untranslated region of the dystrophin gene can be amplified by the polymerase chain reaction and shows length polymorphism in a Caucasian population. The two common alleles differ by 4bp. This new genetic marker has a heterozygosity of about 35% and is typed more rapidly than a conventional restriction fragment length polymorphism. Its localisation at the 3' end of the dystrophin gene makes it a useful tool for diagnostic applications in families with Duchenne/Becker muscular dystrophy, and for the analysis of intragenic recombination.

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