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An in vitro evaluation of HRE 664, a novel penem antibiotic

✍ Scribed by Fuchs, Peter C.; Barry, Arthur L.; Jones, Ronald N.; Aldridge, Kenneth E.

Book ID
122044135
Publisher
Elsevier Science
Year
1988
Tongue
English
Weight
590 KB
Volume
11
Category
Article
ISSN
0732-8893

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Desulphurative approaches to penem antibiotics. IV. Bromination of 3-methyl-2-thiacephems, a novel entry in the synthesis of potent antimicrobial agents
✍ Ettore Perrone; Marco Alpegiani; Angelo Bedeschi; Franco Giudici; Maurizio Fogli πŸ“‚ Article πŸ“… 1983 πŸ› Elsevier Science 🌐 French βš– 275 KB

The 3-methyl group in 2-thiacephem-4-carboxylates can be brominated in good yield, thus providing access to a series of highly active penem antibiotics. References and Notes