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An in vitro and in silico study on the flavonoid-mediated modulation of the transport of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) through Caco-2 monolayers

✍ Scribed by Maaike E. Schutte; Andreas P. Freidig; Johannes J.M. van de Sandt; Gerrit M. Alink; Ivonne M.C.M. Rietjens; John P. Groten

Book ID: 113923957
Publisher: Elsevier Science
Year: 2006
Tongue: English
Weight: 514 KB
Volume: 217
Category: Article
ISSN: 0041-008X
DOI: 10.1016/j.taap.2006.08.005

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## Abstract 2‐amino‐1‐methyl‐6‐phenylimidazo[4,5‐__b__]pyridine (PhIP) is the most abundant heterocyclic amine derived from food, possibly involved in human carcinogenesis. We evaluated the formation of PhIP‐DNA adducts in lymphocytes from 76 incident colorectal cancer patients likely to be exposed