An improvedBacillus subtiliscell factory for producingscyllo-inositol, a promising therapeutic agent for Alzheimer’s disease

Control of Diastereoselectivity in Ortho

Control of Diastereoselectivity in Orthoester Johnson–Claisen Rearrangement of Tartrate-Based Allyl Alcohol: An Efficient Synthesis of Arundic Acid, a Potential Therapeutic Agent for Alzheimer's Disease

✍ Rodney A. Fernandes; Arun B. Ingle; Dipali A. Chaudhari 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 621 KB

## Abstract A diastereoselective orthoester Johnson–Claisen rearrangement has been employed in the synthesis of both enantiomers of arundic acid, a potential therapeutic agent against Alzheimer's disease. The effect of solvent, olefin geometry and alcohol chirality on the diastereoselectivity of th