✦ LIBER ✦
Control of Diastereoselectivity in Orthoester Johnson–Claisen Rearrangement of Tartrate-Based Allyl Alcohol: An Efficient Synthesis of Arundic Acid, a Potential Therapeutic Agent for Alzheimer's Disease
✍ Scribed by Rodney A. Fernandes; Arun B. Ingle; Dipali A. Chaudhari
- Publisher
- John Wiley and Sons
- Year
- 2011
- Tongue
- English
- Weight
- 621 KB
- Volume
- 2012
- Category
- Article
- ISSN
- 1434-193X
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✦ Synopsis
Abstract
A diastereoselective orthoester Johnson–Claisen rearrangement has been employed in the synthesis of both enantiomers of arundic acid, a potential therapeutic agent against Alzheimer's disease. The effect of solvent, olefin geometry and alcohol chirality on the diastereoselectivity of the orthoester Johnson–Claisen rearrangement of a tartrate‐based allyl alcohol has been studied.