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An improved tripod amphiphile for membrane protein solubilization

✍ Scribed by Seungju M. Yu; D. Tyler McQuade; Mariah A. Quinn; Christian P.R. Hackenberger; Samuel H. Gellman; Mark P. Krebs; Arthur S. Polans

Book ID
111753753
Publisher
Cold Spring Harbor Laboratory Press
Year
2000
Tongue
English
Weight
492 KB
Volume
9
Category
Article
ISSN
0961-8368

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The shape of an amphiphile strongly influences selfassociation in solution [1] and in liquid crystalline phases, [2] as well as interactions with self-assembled structures such as lipid bilayers. [3] In recent years several groups have examined unusual amphiphile topologies. [4, 5] We and others, fo

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We have studied the effect of adding sucrose distearate (2C(18)SE) on the solubilization capacity of microemulsions formed in the water/C(12)EO(6)/n-decane system. Upon addition of 2C(18)SE to the binary water/C(12)EO(6) system, a lamellar liquid crystal region developed. This suggests that the rigi