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An improved synthesis of β-keto ester units in didemnins, using 2,2'-carbonyl-bis(3,5-dioxo-4-methyl-1,2,4-oxadiazolidine)

✍ Scribed by Patrick Jouin; Joël Poncet; Marie-Noelle Dufour; Isabelle Maugras; Antoine Pantaloni; Bertrand Castro


Publisher
Elsevier Science
Year
1988
Tongue
French
Weight
256 KB
Volume
29
Category
Article
ISSN
0040-4039

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2,2′-carbonyl-bis(3,5-dioxo-4-methyl-1,2
✍ Michel Denarié; Denis Grehouillat; Thierry Malfroot; Jean-Pierre Senet; Gérard S 📂 Article 📅 1987 🏛 Elsevier Science 🌐 French ⚖ 210 KB

2,2'-Carbonyl bis (3,5-dioxo-4-methyl-1,2,4-oxadiazolidine) was prepared and used for the synthesis of various carbamates and dipeptides. 3,5-Dioxo-1,2,4-oxadiazolidines have been found as a part of the natural excitatory aminoacid guisgualic acid and their synthesis has been extensively studied by