Reaction of carboxylic acids including N-protected a-amino acids with 2,2 f-carbonyl bis(3,5-dioxo-4-methyl-1,2,4-oxadiazolidine) and alcohols affords the corresponding esters under mild conditions.
✦ LIBER ✦
An improved synthesis of β-keto ester units in didemnins, using 2,2'-carbonyl-bis(3,5-dioxo-4-methyl-1,2,4-oxadiazolidine)
✍ Scribed by Patrick Jouin; Joël Poncet; Marie-Noelle Dufour; Isabelle Maugras; Antoine Pantaloni; Bertrand Castro
- Publisher
- Elsevier Science
- Year
- 1988
- Tongue
- French
- Weight
- 256 KB
- Volume
- 29
- Category
- Article
- ISSN
- 0040-4039
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2,2'-Carbonyl bis (3,5-dioxo-4-methyl-1,2,4-oxadiazolidine) was prepared and used for the synthesis of various carbamates and dipeptides. 3,5-Dioxo-1,2,4-oxadiazolidines have been found as a part of the natural excitatory aminoacid guisgualic acid and their synthesis has been extensively studied by
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