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An Improved Synthesis of the “Miracle Nutrient” Coenzyme Q 10

✍ Scribed by Lipshutz, Bruce H.; Lower, Asher; Berl, Volker; Schein, Karin; Wetterich, Frank


Book ID
126444871
Publisher
American Chemical Society
Year
2005
Tongue
English
Weight
52 KB
Volume
7
Category
Article
ISSN
1523-7060

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A classic in the area of organic synthesis, Strategies and Tactics in Organic Synthesis provides a forum for investigators to discuss their approach to the science and art of organic synthesis. Rather than a simple presentation of data or a second-hand analysis, we are given stories that vividly dem

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An improved route to coenzyme Q 10 (1) starting from commercially available coenzyme Q 1 is described. The key steps in this synthesis are the SeO 2 -mediated oxidation of the protected isoprenylhydroquinone 3 into the (E)-allyl alcohol 5 without the formation of undesired stereoisomer and the one-p

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An efficient and stereoselective approach to the synthesis of coenzyme Q 10 is described (Scheme). The MeOCH 2 -protected p-hydroquinone 4 containing the C 5 (E)-allyl (tert-butyl)dimethylsilyl ether moiety was obtained via a halogen -lithium exchange of the MeOCH 2 -proctected 2-bromo-5,6dimethoxy-