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An improved synthesis of ethanal-1-13C

✍ Scribed by Didier Barbry; Daniel Couturier

Publisher: John Wiley and Sons
Year: 1987
Tongue: French
Weight: 131 KB
Volume: 24
Category: Article
ISSN: 0022-2135
DOI: 10.1002/jlcr.2580240516

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✦ Synopsis

The title compound is obtained from sodium acetate-1 -C by a shorter synthesis than the usual one . In the last step, acetyl chloride-1 J3C is reduced by tri- 13 butyltin hydride with palladium(0) complexe .

Kev word.

Ethanal, Carbon labelling Ethanal has a widespread use in synthesis of labelled compounds . We needed the 113 C enriched compound for preparation and spectroscopic study 13 of thiazolidines-2-C , so it seems of interest to improve the yields of its preparation .

13

Ethanal-l-C is generally obtained by reaction of sodium acetate-1 3C with an acyl chloride , reduction of the acetyl chloride to the labelled ethanol and oxidation of the alcohol 1 .

Since the Rosenmund process2, many reagents have been used to achieve the one-step reduction of acyl chlorides to aldehydes . Included among these were organosilicon hydrides3 , tri-tert-butoxyaluminium hydride ' , bis

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