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An improved synthesis of dideuterated thioridazine with the label in the piperidine ring

✍ Scribed by T. Mohammad; E. M. Hawes; G. McKay; K. K. Midha

Publisher
John Wiley and Sons
Year
1990
Tongue
French
Weight
290 KB
Volume
28
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

2‐(2‐Hydroxyethyl)‐1‐methyl [6,6‐^2^H~2~]piperidine was obtained by a new route from 2‐(2‐hydroxyethyl)‐piperidine. This enabled dideuterated (±)‐thioridazine to be obtained by an improved approach. The key steps involved ruthenium tetroxide oxidation of the N, O‐diacetylated starting material and subsequent lithium aluminum deuteride reduction of O‐acetylated 2‐(2‐hydroxyethyl)‐6‐pieridinone.

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