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An Improved Synthesis of Canthin-6-one

✍ Scribed by Czerwinski, Kevin M.; Zificsak, Craig A.; Stevens, John; Oberbeck, Melissa; Randlett, Christopher; King, Melissa; Mennen, Steve

Book ID
115315691
Publisher
Taylor and Francis Group
Year
2003
Tongue
English
Weight
169 KB
Volume
33
Category
Article
ISSN
0039-7911

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πŸ“œ SIMILAR VOLUMES

An Improved Synthesis of Canthin-6-one.
An Improved Synthesis of Canthin-6-one.
✍ Kevin M. Czerwinski; Craig A. Zificsak; John Stevens; Melissa Oberbeck; Christop πŸ“‚ Article πŸ“… 2003 πŸ› John Wiley and Sons βš– 94 KB
Single electron transfer induced total s
Single electron transfer induced total synthesis of canthin-6-one
✍ Ulrich Râßler; Siegfried Blechert; Eberhard Steckhan πŸ“‚ Article πŸ“… 1999 πŸ› Elsevier Science 🌐 French βš– 175 KB

The cytotoxic alkaloid canthin-6-one was synthesized from harmalane in a short sequence (six steps) with good overall yield (18%) using a single electron transfer (SET) induced radical cationic hetero [4+2] cycloaddition as high yielding key step.

Synthesis of 1-methoxy canthine-6-one
Synthesis of 1-methoxy canthine-6-one
✍ Timothy J. Hagen; James M. Cook πŸ“‚ Article πŸ“… 1988 πŸ› Elsevier Science 🌐 French βš– 221 KB

The six step synthesis of the cytotoxic antileukemic alkaloid 1-methoxy canthine-&one 2 is described. The pivotal steps m represented by the oxidation (DDQ) of 9 to tiord the 3-acylindole 14 and the conversion of 11 into the 4-methoxy-1-alkyl fl-carboline 15. A number of canthine-6-one alkaloids h