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An improved synthesis of [2.2.3]cyclazines from 3H-pyrrolizines

✍ Scribed by Volker Batroff; Wilhelm Flitsch; Wilfried Lübisch; Derek Leaver; David Skinner


Book ID
104220729
Publisher
Elsevier Science
Year
1982
Tongue
French
Weight
203 KB
Volume
23
Category
Article
ISSN
0040-4039

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The thermally induced ring expansion of 4-(I-pyrrolyl)-4trimethylsiloxycyctobutenones to 5hydroxy-8-trimethylsiloxyindolirines and their subsequent oxidatbn to the rare indolizine-5,8-dbnes is described. When the rearrangement is carried out in the presence of DMAD the indoliiines are trapped in an