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An improved synthesis and evaluation in pig brain of the dopamine agonist ligand: R-[N-methyl-11C]apomorphine

✍ Scribed by N. M. Gillings; P. Cumming

Book ID
112132881
Publisher
John Wiley and Sons
Year
2001
Tongue
French
Weight
150 KB
Volume
44
Category
Article
ISSN
0022-2135

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## Abstract 2‐Fluoronorapomorphine, the PET labelling precursor to 2‐fluoro‐__N__‐[^11^C]propylnorapomorphine, was prepared in 13 steps from codeine in a total yield of 10 %. Codeine was converted in four steps into __N__‐benzylnorcodeine which was oxidised by using the Swern protocol. Subsequent a