## Abstract The stereoselective synthesis of the naturally occurring dihydropyranone rugulactone has been accomplished starting from 3โphenylpropanโ1โol employing __Maruoka__ allylation and ringโclosing metathesis as the key steps.
โฆ LIBER โฆ
An improved stereoselective total synthesis of (R)-rugulactone
โ Scribed by Abhishek Goswami; Partha Pratim Saikia; Bishwajit Saikia; Devdutt Chaturvedi; Nabin C. Barua
- Book ID
- 113929795
- Publisher
- Elsevier Science
- Year
- 2011
- Tongue
- French
- Weight
- 253 KB
- Volume
- 52
- Category
- Article
- ISSN
- 0040-4039
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The total synthesis of the novel antimalarial drug, a sesquiterpene endoperoxide, (+)-artemisinin is described. The approach is flexible and stereoselective. The use of an intermolecular radical reaction on an intermediate iodolactone and a Wittig reaction on a ketone were employed for the synthesis