An improved procedure for the preparation of aminomethyl polystyrene resin and its use in solid phase (peptide) synthesis
✍ Scribed by Paul W.R. Harris; Sung Hyun Yang; Margaret A. Brimble
- Book ID
- 113929979
- Publisher
- Elsevier Science
- Year
- 2011
- Tongue
- French
- Weight
- 254 KB
- Volume
- 52
- Category
- Article
- ISSN
- 0040-4039
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📜 SIMILAR VOLUMES
## a-Amidoalkylation Partial hydrolysis Solid-phase peptide synthesis a b s t r a c t MBHA (4-methylbenzhydrylamine) resin has been extensively used as a solid support for the synthesis of peptide amides. Herein, we prepared the core-shell-type MBHA resin by benzotriazole-catalyzed amidoalkylation
AbstractÐA 1,4-butanediol dimethacrylate cross-linked polystyrene (PS±BDODMA) support was prepared by aqueous suspension polymerization. The C-terminal amino acid incorporation, N a -Fmoc and Boc-deprotection, acylation reactions and the removal of the target peptide from the support were optimized.
## Abstract Well‐characterized resins of high purity are critical for effective solid phase peptide synthesis (SPPS). The quality of commercial (4‐methyl)benzhydrylamine‐resin (MBHA‐resin), used for the synthesis of peptide amides, is not consistent and residual ketone functionalities are frequentl