An improved method of purification of transforming growth factor, type β from platelets
✍ Scribed by James L. Cone; Dennis R. Brown; Joseph E. DeLarco
- Book ID
- 118308745
- Publisher
- Elsevier Science
- Year
- 1988
- Tongue
- English
- Weight
- 286 KB
- Volume
- 168
- Category
- Article
- ISSN
- 0003-2697
No coin nor oath required. For personal study only.
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Transforming growth factor type e (TGFe) is a heat-and acid-stable polypeptide with an apparent molecular weight of 22,000, which stimulates the proliferation of certain epithelial and mesenchymal cells in monolayer and soft agar. TGFe has been purified to homogeneity. Initial acid-ethanol extractio
Stimulation of quiescent cultures of AKR-2B cells with transforming growth factor type P (TGFP) resulted in a transitory increase in actin cytoplasmic poly(A) + RNA. Levels of actin rnRNA peaked approximately 4-8 hours subsequent to TGFP addition and approached basal levels by 24 hours. The accumula