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An improved method for the radiosynthesis of [11C]d-threo-methylphenidate

✍ Scribed by A. R. Studenov; S. Jivan; J. Lu; M. J. Adam; S. B. Jensen; J. P. O'Neil; Y.-S. Ding

Publisher
John Wiley and Sons
Year
2006
Tongue
French
Weight
86 KB
Volume
49
Category
Article
ISSN
0022-2135

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✦ Synopsis

An improved method to remove the 2-nitrophenylsulfenyl protecting group in the conventional radiosynthesis of the PET radiotracer [C-11]d-threo-methylphenidate was developed. The method uses the nonvolatile reagents sulfuric acid and l-cysteine. In addition it was demonstrated that solid phase extraction (SPE, C18 and ion exchange) can be used to purify the final product instead of semi-preparative HPLC.

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