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An improved method for the preparation of 1,2-isopropylidene-SN-glycerol

✍ Scribed by Hansjörg Eibl

Publisher
Elsevier Science
Year
1981
Tongue
English
Weight
258 KB
Volume
28
Category
Article
ISSN
0009-3084

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✦ Synopsis

A simple and fast route for the preparation of 1,2-isopropylidene-sn-glycerol from Dmannitol in 45% yield is described. The value of optical rotation, [a] ~ + 15.2 °, is higher than usual indicating considerable racemization for other procedures, Since 1,2-isopropylidene-sn-glycerol serves as general intermediate for the synthesis of glycerides and of phosphoglycerides these lipids contain substantial amounts of the isomer, for instance 1,2-dipalmitoyl-sn-glycerol-3-phosphocholine may consist of up to 15% of 2,3-dipalmitoyl-sn-glycerol-1-phosphocholine in earlier preparations,

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