An improved method for the measurement of the angiotensin-converting enzyme inhibitor lisinopril in human plasma by stable isotope dilution gas chromatography/negative ion chemical ionization mass spectrometry

✍ Scribed by H. J. Leis; G. Fauler; G. Raspotnig; W. Windischhofer

• Publisher: John Wiley and Sons
• Year: 1999
• Tongue: English
• Weight: 40 KB
• Volume: 13
• Category: Article
• ISSN: 0951-4198
• DOI: 10.1002/(sici)1097-0231(19990430)13:8<650::aid-rcm536>3.0.co;2-x

✦ Synopsis

An improved method for the quantitative measurement of the angiotensin-converting enzyme inhibitor lisinopril in human plasma is presented. The assay is based on gas chromatography/negative ion chemical ionization mass spectrometry. The method involves solid phase extraction on C18 sorbent and derivatization to the pentafluorobenzyl diester trifluoroacetamide derivatives.