An improved method for preparing tritium labeled fluoxetine

✍ Scribed by Richard S. P. Hsi; Wayne T. Stolle

• Publisher: John Wiley and Sons
• Year: 1996
• Tongue: French
• Weight: 122 KB
• Volume: 38
• Category: Article
• ISSN: 0022-2135
• DOI: 10.1002/(sici)1099-1344(199612)38:12<1147::aid-jlcr926>3.0.co;2-r

✦ Synopsis

Palladium-on-charcoal catalyzed reduction of N-methyl-3-(3-bromo)phenyl-3-(4-trifluoromethyl)phenoxypropylamine (1) with tritium gas produces a mixture of the debrominated product [3H]fluoxetine (2) and N-methyl-3-[3-3Hlphenylpropylamine(3), which results from cleavage of the benzylic carbon-oxygen bond. Carrying out this reaction in the presence of pyridine eliminates hydrogenolysis and produces [3H]fluoxetine as the sole product.