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An Improved Direct Oxidation of Alkyl Halides to Aldehydes

โœ Scribed by Dave, Paritosh; Byun, Hoe-Sup; Engel, Robert


Book ID
120980278
Publisher
Taylor and Francis Group
Year
1986
Tongue
English
Weight
118 KB
Volume
16
Category
Article
ISSN
0039-7911

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An improved method for direct conversion
โœ Thomas A. Engler; Kelly Furness; Sushant Malhotra; Clive Diefenbacher; Joshua R. ๐Ÿ“‚ Article ๐Ÿ“… 2003 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 107 KB

Treatment of heteroaryl-aldehydes with diethyl cyanophosphonate in the presence of a catalytic amount of LiCN affords phosphorylated cyanohydrins which are reduced in situ with SmI 2 to give heteroaryl-acetonitriles in generally good overall yields (50-100%). The generality of the process is demonst