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An improved method for direct conversion of heteroaryl-aldehydes to heteroaryl-acetonitriles

✍ Scribed by Thomas A. Engler; Kelly Furness; Sushant Malhotra; Clive Diefenbacher; Joshua R. Clayton

Book ID: 104253291
Publisher: Elsevier Science
Year: 2003
Tongue: French
Weight: 107 KB
Volume: 44
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(03)00427-1

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✦ Synopsis

Treatment of heteroaryl-aldehydes with diethyl cyanophosphonate in the presence of a catalytic amount of LiCN affords phosphorylated cyanohydrins which are reduced in situ with SmI 2 to give heteroaryl-acetonitriles in generally good overall yields (50-100%). The generality of the process is demonstrated.

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