An Improved and Economical Process for the Manufacture of the Key Intermediate of Aliskiren, a New Potent Renin Inhibitor
β Scribed by Wang, Fan; Xu, Xiao-Ying; Wang, Fei-Ying; Peng, Lin; Zhang, Yong; Tian, Fang; Wang, Li-Xin
- Book ID
- 121366549
- Publisher
- American Chemical Society
- Year
- 2013
- Tongue
- English
- Weight
- 230 KB
- Volume
- 17
- Category
- Article
- ISSN
- 1083-6160
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## Abstract The diastereoselective synthesis of the sterically hindered, __Ξ³__βbranched __Ξ±__βamino acid derivative (2__S__,4__S__)β**24a** and its __N__β[(__tert__βbutoxy)carbonyl](Boc)βprotected alcohol (2__S__,4__S__)β**19**, both key intermediates of a novel class of nonpeptide renin inhibitors