## Abstract ## Purpose To validate the accuracy of T1 measurement by three‐dimensional Look‐Locker method (3D LL) for delayed gadolinium‐enhanced MRI of cartilage (dGEMRIC) of human subjects with and without osteoarthritis (OA), as compared with two‐dimensional inversion recovery fast spin‐echo (2
An improved 3-D Look–Locker imaging method for T1 parameter estimation
✍ Scribed by Ken Nkongchu; Giles Santyr
- Publisher
- Elsevier Science
- Year
- 2005
- Tongue
- English
- Weight
- 343 KB
- Volume
- 23
- Category
- Article
- ISSN
- 0730-725X
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✦ Synopsis
The 3-D Look-Locker (LL) imaging method has been shown to be a highly efficient and accurate method for the volumetric mapping of the spin lattice relaxation time T(1). However, conventional 3-D LL imaging schemes are typically limited to small tip angle RF pulses (5 degrees ), thereby improving the SNR and the accuracy of the method. In phantom studies, a mean T(1) measurement accuracy of less than 2% (0.2-3.1%) using a tip angle of 10 degrees was obtained for a range of T(1) from approximately 300 to 1,700 ms with a measurement time increase of only 15%. This accuracy compares favorably with the conventional 3-D LL method that provided an accuracy between 2.2% and 7.3% using a 5 degrees flip angle.
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