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An Impaired Response of Adenylate Cyclase to Stimulation by Epinephrine in Adipocyte Plasma Membranes from Genetically Obese Mice (ob/ob)

✍ Scribed by Marie-Hèléne LAUDAT; Jacques PAIRAULT


Book ID
115114594
Publisher
John Wiley and Sons
Year
1975
Tongue
English
Weight
593 KB
Volume
56
Category
Article
ISSN
1432-1327

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The regulation of adenylate cyclase in a
✍ R. R. French; D. A. York 📂 Article 📅 1984 🏛 Springer 🌐 English ⚖ 719 KB

Adenylate cyclase activity was determined using a purified plasma membrane fraction prepared from isolated adipocytes by a Percoll gradient centrifugation procedure. The activation of adenylate cyclase by isoprenaline was reduced by approximately 50% in membranes from obese mice, although no reducti