An identical novel mutation in BRCA1 and a common haplotype in familial ovarian cancer in non-Ashkenazi Jews
β Scribed by Theodor, L; Bar-Sade, R; Kruglikova, A; Ben-Baruch, G; Risel, S; Shiri-Sverdlov, R; Hirsh Yechezkel, G; Modan, B; Papa, MZ; Rechavi, G
- Book ID
- 109837535
- Publisher
- Nature Publishing Group
- Year
- 1998
- Tongue
- English
- Weight
- 853 KB
- Volume
- 77
- Category
- Article
- ISSN
- 0007-0920
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The 185delAG and 5382insC founder mutations account for the majority of mutations identified in BRCA1 in Ashkenazi Jewish breast and breast-ovarian cancer families. Few non-founder BRCA1 mutations have been identified to date in these families. We initially screened a panel of 245 Ashkenazi Jewish b
Ovarian cancer is a clinically important cancer in Turkey. The contribution of BRCA1 and BRCA2 to ovarian cancer in Turkish patients has not previously been described. In this study we investigated the presence of BRCA1 and BRCA2 mutations in 102 consecutively ascertained, hospital-based, ovarian ca