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An extremely simple, convenient and mild one-pot reduction of carboxylic acids to alcohols using 3,4,5-trifluorophenylboronic acid and sodium borohydride

โœ Scribed by R.H. Tale; K.M. Patil; S.E. Dapurkar

Publisher
Elsevier Science
Year
2003
Tongue
French
Weight
69 KB
Volume
44
Category
Article
ISSN
0040-4039

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โœฆ Synopsis

Acyloxyboron intermediates formed in situ from carboxylic acids and 3,4,5-trifluorophenylboronic acids react with sodium borohydride in THF to give alcohols in good to high yields.

๐Ÿ“œ SIMILAR VOLUMES

Mild reduction of carboxylic acids to al
Mild reduction of carboxylic acids to alcohols using cyanuric chloride and sodium borohydride
โœ Massimo Falorni; Andrea Porcheddu; Maurizio Taddei ๐Ÿ“‚ Article ๐Ÿ“… 1999 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 125 KB

Several carboxylic acids, including N-Boo, N-Cbz and N-Fmoe amino acids were reduced to the corresponding alcohols by activation of the carboxy function with cyanuric chloride and N-methylmorpholine followed by reduction with aqueous sodium borohydride.