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An external chiral amidophosphine ligand for asymmetric conjugate addition of organocopper

โœ Scribed by Yuichi Nakagawa; Motomu Kanai; Yasuo Nagaoka; Kiyoshi Tomioka

Publisher
Elsevier Science
Year
1998
Tongue
French
Weight
741 KB
Volume
54
Category
Article
ISSN
0040-4020

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โœฆ Synopsis

Two types of external, chiral amidophosphine ligands, 1-5, were prepared. Examination of their behavior in an asymmetric conjugate addition reaction of organocuprate revealed the possibility for steric tuning to realize high selectivity.

๐Ÿ“œ SIMILAR VOLUMES

Asymmetric conjugate addition of organoc
Asymmetric conjugate addition of organocopper-amidophosphine reagents to cycloalkenones
โœ Motomu Kanai; Kiyoshi Tomioka ๐Ÿ“‚ Article ๐Ÿ“… 1994 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 322 KB

Mediated by a noncovalently bound chiral amidophosphine iigand I, reaction of organocoppers with cycloalkenones 2 aforded the corresponding J-substituted cyclo-aLk-anones 3 in 9568% ee.