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An expeditious approach to 1-(isoquinolin-1-yl)guanidines via a three-component reaction of 2-alkynylbenzaldehyde, sulfonohydrazide, with carbodiimide

✍ Scribed by Huanhuan Wang; Shengqing Ye; Hanpeng Jin; Jianping Liu; Jie Wu

No coin nor oath required. For personal study only.

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## Abstract Among the novel isoquinolinylguanidines (IV), (VI) prepared, compounds with promising PTP1B inhibiting activity are identified.

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