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An expedient one-pot synthesis for protected 2-thia-5-azabicyclo[2.2.1]heptan-3-ones. Versatile intermediates in the synthesis of carbapenem sidechains

✍ Scribed by K.M.J. Brands; G. Marchesini; J.M. Williams; U.-H. Dolling; P.J. Reider

Publisher
Elsevier Science
Year
1996
Tongue
French
Weight
253 KB
Volume
37
Category
Article
ISSN
0040-4039

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## Abstract An efficient synthesis of 1,2,3,4‐tetrahydro‐2‐pyrimidinones and ‐thiones using ferric perchlorate as the catalyst from an aldehyde, ethyl acetoacetate, and urea or thiourea in acetonitrile was described. Compared to the classical Biginelli reaction conditions, this new method consisten