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An examination of the potential effect of lipids on the first-pass metabolism of the lipophilic drug anethol trithione

✍ Scribed by Hong-Zhen Yu; Si-Fei Han; Ping Li; Chun-Liu Zhu; Xin-Xin Zhang; Li Gan; Yong Gan

Book ID
102395737
Publisher
John Wiley and Sons
Year
2011
Tongue
English
Weight
346 KB
Volume
100
Category
Article
ISSN
0022-3549

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πŸ“œ SIMILAR VOLUMES

The ratio of first to zeroth moments of
The ratio of first to zeroth moments of the plasma profile of an oral drug undergoing first-pass and linear reversible metabolism
✍ Haiyung Cheng πŸ“‚ Article πŸ“… 1995 πŸ› John Wiley and Sons 🌐 English βš– 240 KB πŸ‘ 2 views

Based on the convolution integral, equations have been derived for the ratio of the first to the zeroth moments of the plasma concentration-time curve (AUMC/AUC) parameters for a drug (p) undergoing first-pass and reversible metabolism and its reversible metabolite (m). According to these equations,