Effect of allopurinol on the first-pass metabolism of 6-mercaptopurine in the rat
β Scribed by Hitoshi Sasaki; Kimiyoshi Tsuru; Junzo Nakamura; Ryoji Konishi; Juichiro Shibasaki
- Book ID
- 115779908
- Publisher
- Elsevier Science
- Year
- 1987
- Tongue
- English
- Weight
- 224 KB
- Volume
- 36
- Category
- Article
- ISSN
- 0006-2952
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Plasma levels and the area under the plasma concentration-time curve (AUC) values of 6-mercaptopurine (6-MP) were determined in a balanced crossover study of oral (powder) and rectal (macrogol suppository) administration to 5 children with acute lymphoblastic leukaemia (ALL). The AUC (538.6 ng.h.ml-