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An evolutionary model for the origin of modularity in a complex gene network

✍ Scribed by Xun Gu

Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
117 KB
Volume
312B
Category
Article
ISSN
1552-5007

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✦ Synopsis

Abstract

Scale‐free cellular networks are organized into a complex topology by massive interactions (links) between nodes, which can be typically characterized by a power‐law degree. In contrast, almost all cellular networks show the feature of modularity. The popular BA model (Barabasi and Albert) demonstrated the origin of scale‐free property by the attachment preference, but not for the origin of modularity. We propose a BBA model (Biological BA) by introducing the random link‐loss mechanism under the original BA model, showing that scale‐free and modularity can emerge as a derived property of the BBA model. Data analysis has shown that, roughly, the rate of gene network evolution can be described as a 2‐2‐1 pattern (adding two new genes and two new links with the cost of one link‐loss). J. Exp. Zool. (Mol. Dev. Evol.) 312B:75–82, 2009. © 2008 Wiley‐Liss, Inc.

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