An Evolutionary Analytical Model of a Complementary Circular Code Simulating the Protein Coding Genes, the 5′ and 3′ Regions
✍ Scribed by D.G. Arquès; J.-P. Fallot; C.J. Michel
- Publisher
- Springer
- Year
- 1998
- Tongue
- English
- Weight
- 456 KB
- Volume
- 60
- Category
- Article
- ISSN
- 1522-9602
No coin nor oath required. For personal study only.
✦ Synopsis
Several frequency asymmetries unexpectedly observed (e.g. the frequency difference between T 1 and T 2 in the frame 0), are related to a new property of the subset T 0 involving substitutions. An evolutionary analytical model at three parameters ( p, q, t) based on an independent mixing of the 22 codons (trinucleotides in frame 0) of T 0 with equiprobability (1/22) followed by t ≈ 4 substitutions per codon according to the proportions p ≈ 0.1, q ≈ 0.1 and r = 1pq ≈ 0.8 in the three codon sites respectively, retrieves the frequencies of T 0 , T 1 , T 2 observed in the three frames of protein genes and explains these asymmetries. Furthermore, the same model (0.1, 0.1, t) after t ≈ 22 substitutions per codon, retrieves the statistical properties observed in the three frames of the 5 and 3 regions. The complex behaviour of these analytical curves is totally unexpected and a priori difficult to imagine.