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An evaluation of the markers p53 and Ki-67 for their predictive value in prostate cancer

✍ Scribed by Uzoaru, Ike; Rubenstein, Marvin; Mirochnik, Yelena; Slobodskoy, Leonid; Shaw, Michael; Guinan, Patrick

Publisher
John Wiley and Sons
Year
1998
Tongue
English
Weight
32 KB
Volume
67
Category
Article
ISSN
0022-4790

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✦ Synopsis

Background and Objectives: p53 and Ki-67 are but two markers being evaluated for their predictive value in prostate cancer. The purpose of this study was to compare p53 and Ki-67 with age, stage, Gleason score, and ploidy for their prognostic abilities in prostate cancer. Methods: Prostate cancer specimens from 134 patients were immunohistochemically stained for p53 and Ki-67 expression and differences evaluated by SPSS analysis of variance (ANOVA) methods. The dependent variable was patient survival and the independent variables were age, stage, Gleason score, and ploidy. Results: In decreasing order of prediction of survival were stage (P < 0.001), Gleason score (P < 0.001), age (P ‫ב‬ 0.1869), Ki-67 (P ‫ב‬ 0.2284), p53 (P ‫ב‬ 0.4282) and ploidy (P ‫ב‬ 0.8141).

Conclusion:

It is concluded that stage and Gleason score are significant predictors of survival while p53, Ki-67, age and ploidy are not.

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