An EPR Study of the Interactions between Starburst Dendrimers and Polynucleotides
β Scribed by Ottaviani, M. F.; Sacchi, B.; Turro, N. J.; Chen, W.; Jockusch, S.; Tomalia, D. A.
- Book ID
- 126792764
- Publisher
- American Chemical Society
- Year
- 1999
- Tongue
- English
- Weight
- 121 KB
- Volume
- 32
- Category
- Article
- ISSN
- 0024-9297
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## Abstract Spinβprobe and spinβlabel techniques were used to study the interactions of the AΞ² 1β28 peptide involved in Alzheimer disease and the PrP 106β126 peptide suspected to be preferentially involved in spongiform encephalopathies with three different types of dendrimers. A computerβaided EPR
## The intermolecular dendrimer interactions between poly (amidoamine) dendrimers (SBDs ) of different generations (G = 2, 4, and 6) were studied in aqueous solution by EPR and fluorescence depolarization. For the EPR studies a spin probe (TEMPO) was covalently linked to the SBDs, and for the fluo